Autocar's review focuses on the EQS's role as a technological showcase. They praise the car's ultra-low drag coefficient, which translates to excellent real-world efficiency and range. The cabin is a masterpiece of design and materials, with the optional Hyperscreen providing a futuristic feel. However, Autocar notes that the software can be confusing, and the lack of physical buttons for essential functions is a drawback. The ride is exceptionally refined, making it one of the quietest cars on the market. The steering is light and lacks feedback, but the car feels stable at high speeds. The rear seat is very comfortable, but the sloping roofline limits headroom for tall adults. Autocar also mentions that the EQS is not as engaging to drive as the Porsche Taycan, but it's more comfortable and luxurious. The charging infrastructure is a consideration, but the car's 200 kW capability is adequate. Overall, Autocar sees the EQS as a worthy successor to the S-Class in electric form, offering unmatched comfort and technology, though it lacks the dynamic sharpness of some rivals. It's a strong but not perfect luxury EV.

Car and Driver's review of the 2022–2024 Mercedes-Benz EQS praises the luxury EV for its remarkable quietness and serene ride quality, calling it one of the most comfortable vehicles in its class. The interior is lauded for its massive optional Hyperscreen, which spans the entire dashboard and dominates the cabin with futuristic flair. The EQS 450+ achieves an EPA-estimated 350-mile range, which C/D confirmed was nearly matched in real-world highway testing. However, the review criticizes the exterior styling as polarizing—the one-box design sacrifices traditional Mercedes elegance for aerodynamics—and notes that the steering lacks feedback, making the large sedan feel less engaging than its S-Class sibling. The rear seat, despite the car's length, is surprisingly cramped for a full-size flagship. Overall, C/D calls it a technological tour de force and a superb highway cruiser, but not a driver's car. They awarded it a 4.5 out of 5 stars, concluding that it excels in comfort and tech but falls short in dynamism and rear passenger space.