Car and Driver rates the Mercedes-Benz E-Class highly, noting it remains a benchmark in the luxury midsize sedan segment. The review emphasizes the E-Class's serene ride quality, exceptional cabin comfort, and abundant technology. The latest generation benefits from a redesigned interior featuring the MBUX infotainment system with a large central touchscreen, which reviewers find intuitive after a short learning curve. Performance-wise, the E 450's turbocharged inline-six delivers smooth and ample power, while the plug-in hybrid E 350e offers impressive electric-only range for daily commuting. Critics point out that the base engine can feel underwhelming compared to rivals, and the options list is extensive, which can quickly inflate the price. However, the E-Class's combination of refinement, passenger space, and advanced driver-assistance features makes it a top pick. The reviewer also praises the available E 53 AMG variant for adding sportiness without sacrificing comfort. Overall, Car and Driver concludes that the E-Class excels at its primary mission: being a supremely comfortable and composed luxury sedan.

MotorTrend's review of the Mercedes-Benz E-Class highlights the car's dual personality — it can be a plush luxury cruiser or a more engaging sport sedan depending on trim and options. The E 450 with its 3.0-liter turbocharged inline-six engine and 48-volt mild-hybrid system earns praise for smooth, linear acceleration and seamless start-stop operation. MotorTrend appreciates the cabin's high-quality materials and build quality, though they note that the design is more traditional compared to the Tesla Model S or BMW i5 in terms of tech-forward aesthetics. The air suspension, available as an option, is singled out for its ability to absorb road imperfections at highway speeds, making the E-Class an exceptional long-distance tourer. Handling is competent but not class-leading; the E-Class prioritizes comfort over cornering agility. The review also mentions that the E 53 AMG variant provides sharper throttle response and a more aggressive exhaust note for those who want more excitement. MotorTrend recommends the E 450 with the optional air suspension and Driver Assistance Package for the best overall experience.