Car and Driver praises the Mercedes-Benz CLE-Class as a stylish and refined two-door coupe and convertible that effectively replaces the old C-Class and E-Class coupes. The CLE450 variant, with its turbocharged inline-six engine producing 375 horsepower, is highlighted as the standout choice, offering smooth acceleration and a composed, luxurious ride. The interior is noted for its high-quality materials, comfortable front seats, and user-friendly infotainment system with a large touchscreen. Handling is described as secure and predictable, though not as sharp or sporty as rivals like the BMW 4 Series or Audi S5. The rear seat is tight, but acceptable for occasional use. Overall, Car and Driver appreciates the CLE's blend of comfort, technology, and effortless cruising capability, awarding it an Editors' Choice designation. The main criticisms include limited rear-seat space, modest trunk capacity, and the lack of a truly engaging driving experience compared to more performance-oriented competitors. It is recommended primarily as a grand tourer rather than a sports coupe.

MotorTrend's first drive review of the 2024 Mercedes-Benz CLE-Class focuses on the CLE450 4Matic model. The publication describes it as a comfortable, refined, and visually appealing luxury coupe that steps in for the discontinued C-Class and E-Class coupes. The 3.0-liter turbocharged inline-six engine delivers strong, linear power, and the nine-speed automatic transmission shifts smoothly. The cabin is praised for its modern design, premium materials, and advanced MBUX infotainment system, though some controls are noted as overly dependent on touch and steering wheel haptic pads. The ride quality is impressively isolated, making the CLE an excellent long-distance cruiser. However, MotorTrend points out that the handling lacks the agility and sportiness of rivals such as the BMW 440i or Audi S5, and the steering is light with minimal feedback. The convertible version also receives praise for its quiet operation and effective wind management. The CLE450 is seen as an ideal daily driver for those prioritizing comfort and style over outright performance.