Autoblog's review of the 2025 Infiniti QX80 focused on how the redesign addresses the model's historical weaknesses. The new twin-turbo V6 provides ample power, and the nine-speed automatic is smooth and responsive. Autoblog praised the new interior, which finally feels worthy of the luxury price tag, with high-quality materials and an intuitive dual-screen layout. The review noted the QX80's quiet, composed ride and the effectiveness of the ProPILOT Assist system on long highway drives. However, Autoblog pointed out that the QX80's third row remains smaller than those of its American rivals, and the fuel economy is disappointing for a vehicle with such a large fuel tank. The writer also questioned the pricing, noting that a fully loaded Autograph model costs more than a comparable Lincoln Navigator, which offers more space and similar luxury. Autoblog concluded that the QX80 is a dramatically better vehicle than its predecessor, but potential buyers should weigh its strengths against segment leaders with more established luxury credentials.

Edmunds praises the QX80 for its muscular V8 engine, generous passenger space, and plush ride that soaks up bumps with ease. The cabin is quiet and opulent, with available semi-aniline leather and open-pore wood trim. It also shines as a tow vehicle with a maximum rating of 8,500 pounds. However, shortcomings include a clunky infotainment system, poor fuel economy at 15 mpg combined, a third row best left for children due to limited legroom, and ponderous handling with noticeable body lean. Edmunds recommends the QX80 for shoppers wanting a traditional body-on-frame SUV with a strong engine and luxurious interior, but cautions that newer unibody rivals offer better ride quality, more advanced technology, and superior fuel efficiency. The 2024 refresh helps modernize the experience but the QX80 still lags in overall refinement.