The Independent's review of Zach Cregger's Resident Evil reboot describes it as a brilliantly funny film for people who are terrible at video games. The critic notes the film is incredibly faithful to the blockbuster game series while delivering enough bloody elegance to satisfy non-gamers. It combines comedy with horror in a funny, delirious symphony of cartwheeling, flesh-and-bones zorbing balls and exploding blood bubbles. The review praises Cregger's skillful momentum, comparing it favorably to his previous work on Barbarian and Weapons, and gives a strong positive verdict, saying the film is a strange, delightful concoction that captures the experience of playing the games with escalating fear and sublime ridiculousness.

Slashfilm's review of Resident Evil gives the film a 7.5 out of 10, calling it a lean, mean gross-out machine. The critic describes Zach Cregger's game adaptation as consistently funny, frequently scary, and unapologetically gross, like running through the best carnival haunted house. The film is trimmed to a brisk 90 minutes, making it breathless fun as protagonist Bryan sprints from one blood-drenched location to the next. However, the subplot about Bryan's girlfriend's pregnancy is undercooked, and the story is thin if examined closely. Despite this, the movie is so breezy and gruesome that it is hard not to enjoy, with praise for creature designs and Bryan's grumbling, relatable demeanor. It concludes that this is probably Cregger's most entertaining movie so far and a perfect spooky season treat.